Williams血液学（第9版）(英文版）

权威、全面、全新、全彩 举世公认的血液学经典著作 基础与实践 实验与临床 诊断与鉴别 ……………… ※编辑推荐※ ☆经典名著 ： 《Williams血液学》是血液学领域公认的经典之作，经过多次修订，指导了一代又一代的临床医生、生物学研究者和众多学科的实习生。作者们均是各 自领域的学术带头人，他们的基础和临床成果得到了国际广泛认可。 ☆内容全面 ：共139章，涵盖了血液学的所有方面。前半部分讨论了患者临床评估、血液病的分子学和细胞学基础，后半部分具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓，以及输血医学。包含彩图1300余幅。 ☆与时俱进 ：《Williams血液学（第9版）》在基础科学、转换病理生理学和临床实践方面做了大篇幅的修改和更新，以反映血液学领域最新的研究进展。 ☆印刷精美 ： 全书彩色印刷，包含大量极具诊断价值的细胞形态学图片，使阅读和查找更加直观、方便。 ……………… ※内容简介※ 《Williams血液学》是血液学领域的经典之作，涵盖了血液学的所有方面，介绍了患者临床评估、血液病的分子学和细胞学基础，并具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓、输血医学等内容。 第9版在第8版的基础上做了大篇幅的修改和更新，以反映血液学领域的最新进展。新增加了表观遗传学和基因组学、血液肿瘤细胞的新陈代谢和肝素诱导性血小板减少症等内容。 本书是血液科临床医生、实习生、血液学研究人员必不可少的案头佳作，也是学习血液学专业英语的工具书。

简 目 Contributors Preface PART I Clinical Evaluation of the Patient PART II The Organization of the Lymphohematopoietic Tissues PART III Epochal Hematology PART IV Molecular and Cellular Hematology PART V Therapeutic Principles PART VI The Erythrocyte PART VII Neutrophils, Eosinophils, Basophils, and Mast Cells PART VIII Monocytes and Macrophages PART IX Lymphocytes and Plasma Cells PART X Malignant Myeloid Diseases PART XI Malignant Lymphoid Diseases PART XII Hemostasis and Thrombosis PART XIII Transfusion Medicine Index v 目 录 Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xxi PART I Clinical Evaluation of the Patient 1. Initial Approach to the Patient: History and Physical Examination 2. Examination of Blood Cells 3. Examination of The Marrow 4. Consultative Hematology PART II The Organization of the Lymphohematopoietic Tissues 5. Structure of the Marrow and the Hematopoietic Microenvironment 6. The Organization and Structure of Lymphoid Tissues PART III Epochal Hematology 7. Hematology of the Fetus and Newborn 8. Hematology during Pregnancy 9. Hematology in Older Persons PART IV Molecular and Cellular Hematology 10. Genetic Principles and Molecular Biology 11. Genomics 12. Epigenetics 13. Cytogenetics and Genetic Abnormalities 14. Metabolism of Hematologic Neoplastic Cells 15. Apoptosis Mechanisms: Relevance to the Hematopoietic System 16. Cell-Cycle Regulation and Hematologic Disorders 17. Signal Transduction Pathways 18. Hematopoietic Stem Cells, Progenitors, and Cytokines 19. The Inflammatory Response 20. Innate Immunity 21. Dendritic Cells and Adaptive Immunity PART V Therapeutic Principles 22. Pharmacology and Toxicity of Antineoplastic Drugs 23. Hematopoietic Cell Transplantation 24. Treatment of Infections in The Immunocompromised Host 25. Antithrombotic Therapy 26. Immune Cell Therapy 27. Vaccine Therapy 28. Therapeutic Apheresis: Indications, Efficacy, and Complications 29. Gene Therapy for Hematologic Diseases 30. Regenerative Medicine: Multipotential Cell Therapy for Tissue Repair PART VI The Erythrocyte 31. Structure and Composition of the Erythrocyte 32. Erythropoiesis 33. Erythrocyte Turnover 34. Clinical Manifestations and Classification of Erythrocyte Disorders 35. Aplastic Anemia: Acquired and Inherited. 36. Pure Red Cell Aplasia 37. Anemia of Chronic Disease 38.The Congenital Dyserythropoietic Anemias 39.Paroxysmal Nocturnal Hemoglobinuria 40.Paroxysmal Nocturnal Hemoglobinuria 41.Folate, Cobalamin, and Megaloblastic Anemias 42. Iron Metabolism 43. Iron Deficiency and Overload 44.Anemia Resulting from Other Nutritional Deficiencies 45.Anemia Associated with Marrow Infiltration 46.Erythrocyte Membrane Disorders 47.Erythrocyte Enzyme Disorders 48.The Thalassemias: Disorders of Globin Synthesis 49.Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities 50.Methemoglobinemia and Other Dyshemoglobinemias 51.Fragmentation Hemolytic Anemia 52.Erythrocyte Disorders as a Result of Chemical and Physical Agents 53.Hemolytic Anemia Resulting from Infections with Microorganisms 54.Hemolytic Anemia Resulting from Immune Injury 55.Alloimmune Hemolytic Disease of the Fetus and Newborn 56.Hypersplenism and Hyposplenism 57.Primary and Secondary Erythrocytoses 58. The Porphyrias 59. Polyclonal and Hereditary Sideroblastic Anemias PART VII Neutrophils, Eosinophils, Basophils, and Mast Cells 60.Structure and Composition of Neutrophils,Eosinophils, and Basophils 61.Production, Distribution, and Fate of Neutrophils 62.Eosinophils and Related Disorders 63.Basophils, Mast Cells, and Related Disorders 64.Classification and Clinical Manifestations of Neutrophil Disorders 65.Neutropenia and Neutrophilia 66.Disorders of Neutrophil Function PART VIII Monocytes and Macrophages 67.Structure, Receptors, and Functions of Monocytes and Macrophages 68.Production, Distribution, and Activation of Monocytes and Macrophages 69.Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages 70.Monocytosis and Monocytopenia 71.Inflammatory and Malignant Histiocytosis 72.Gaucher Disease and Related Lysosomal Storage Diseases 73.PART IX Lymphocytes and Plasma Cells 73. The Structure of Lymphocytes and Plasma Cells 74. Lymphopoiesis Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production 75.Functions of T Lymphocytes: T-Cell Receptors for Antigen 76.Functions of Natural Killer Cells 77.Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders 79. Lymphocytosis and Lymphocytopenia 80. Immunodeficiency Diseases 81. Hematologic Manifestations of Acquired Immunodeficiency Syndrome 82. Mononucleosis Syndromes PART X Malignant Myeloid Diseases 83. Classification and Clinical Manifestations of the Clonal Myeloid Disorders 84. Polycythemia Vera 85. Essential Thrombocythemia 86. Primary Myelofibrosis 87. Myelodysplastic Syndromes 88. Acute Myelogenous Leukemia 89. Chronic Myelogenous Leukemia and Related Disorders PART XI Malignant Lymphoid Diseases 90. Classification of Malignant Lymphoid Disorders 91. Acute Lymphoblastic Leukemia 92. Chronic Lymphocytic Leukemia 93. Hairy Cell Leukemia 94. Large Granular Lymphocytic Leukemia 95. General Considerations for Lymphomas: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease 96. Pathology of Lymphomas. 97. Hodgkin Lymphoma 98. Diffuse Large B-Cell Lymphoma and Related Diseases 99. Follicular Lymphoma 100. Mantle Cell Lymphoma 101. Marginal Zone B-Cell Lymphomas 102. Burkitt Lymphoma 103. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome) 104. Mature T-Cell and Natural Killer Cell Lymphomas 105. Plasma Cell Neoplasms: General Considerations 106. Essential Monoclonal Gammopathy 107. Myeloma. 108. Immunoglobulin Light-Chain Amyloidosis 109. Macroglobulinemia. 110. Heavy-Chain Disease PART XII Hemostasis and Thrombosis 111. Megakaryopoiesis and Thrombopoiesis 112. Platelet Morphology, Biochemistry, and Function 113. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis 114. Control of Coagulation Reactions 115. Vascular Function in Hemostasis 116. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis 117. Thrombocytopenia 118. Heparin-Induced Thrombocytopenia 119. Reactive Thrombocytosis 120. Hereditary Qualitative Platelet Disorders 121. Acquired Qualitative Platelet Disorders 122. The Vascular Purpuras 123.Hemophilia A and Hemophilia B 124.Inherited Deficiencies of Coagulation Factors II, V,V+VIII, VII, X, XI, and XII 125.Hereditary Fibrinogen Abnormalities 126.von Willebrand Disease 127.Antibody-Mediated Coagulation Factor Deficiencies 128.Hemostatic Alterations in Liver Disease and Liver Transplantation 129.Disseminated Intravascular Coagulation 130. Hereditary Thrombophilia 131.The Antiphospholipid Syndrome 132.Thrombotic Microangiopathies 133. Venous Thrombosis 134.Atherothrombosis: Disease Initiation, Progression,and Treatment 135.Fibrinolysis and Thrombolysis PART XIII Transfusion Medicine 136.Erythrocyte Antigens and Antibodies 137.Human Leukocyte and Platelet Antigens 138.Blood Procurement and Red Cell Transfusion 139.Preservation and Clinical Use of Platelets Index

考杉斯基(Kaushansky)博士是纽约州立大学石溪分校健康科学院的高级副总裁，同时担任该校医学院院长的职务。考杉斯基(Kaushansky)博士是全球知名的血液学专家，发表过多篇有影响力的著作。担任《Willians血液学》第8版、第9版的主编。

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