Molecular Biology, 5th Edition

Molecular Biology, 5/e by Robert Weaver, is designed for an introductory course in molecular biology. Molecular Biology 5/e focuses on the fundamental concepts of molecular biology emphasizing experimentation. In particular author, Rob Weaver, focuses on the study of genes and their activities at the molecular level. Through the combination of excellent illustrations and clear, succinct writing students are presented fundamental molecular biology concepts.

About the Author iv Preface xiii Acknowledgments xvii Guide to Experimental Techniques in Molecular Biology xix PART I Introduction 1 A Brief History 1 2 The Molecular Nature of Genes 12 3 An Introduction to Gene Function 30 PART II Methods in Molecular Biology 4 Molecular Cloning Methods 49 5 Molecular Tools for Studying Genes and Gene Activity 75 PART III Transcription in Bacteria 6 The Mechanism of Transcription in Bacteria 121 7 Operons: Fine Control of Bacterial Transcription 167 8 Major Shifts in Bacterial Transcription 196 9 DNA–Protein Interactions in Bacteria 222 PART IV Transcription in Eukaryotes 10 Eukaryotic RNA Polymerases and Their Promoters 244 11 General Transcription Factors in Eukaryotes 273 12 Transcription Activators in Eukaryotes 314 13 Chromatin Structure and Its Effects on Transcription 355 PART V Post-Transcriptional Events 14 RNA Processing I: Splicing 394 15 RNA Processing II: Capping and Polyadenylation 436 16 Other RNA Processing Events and Post-Transcriptional Control of Gene Expression 471 PART VI Translation 17 The Mechanism of Translation I: Initiation 522 18 The Mechanism of Translation II: Elongation and Termination 560 19 Ribosomes and Transfer RNA 601 PART VII DNA Replication, Recombination, and Transposition 20 DNA Replication, Damage, and Repair 636 21 DNA Replication II: Detailed Mechanism 677 22 Homologous Recombination 709 23 Transposition 732 PART VIII Genomes 24 Introduction to Genomics: DNA Sequencing on a Genomic Scale 759 25 Genomics II: Functional Genomics, Proteomics, and Bioinformatics 789 Glossary 827 Index 856

Rob Weaver was born in Topeka, Kansas, and grew up in Arlington, Virginia. He received his bachelor’s degree in chemistry from the College of Wooster in Wooster, Ohio, in 1964. He earned his Ph.D. in biochemistry at Duke University in 1969, then spent two years doing postdoctoral research at the University of California, San Francisco, where he studied the structure of eukaryotic RNA polymerases with William J. Rutter. He joined the faculty of the University of Kansas as an assistant professor of biochemistry in 1971, was promoted to associate professor, and then to full professor in 1981. In 1984, he became chair of the Department of Biochemistry, and served in that capacity until he was named Associate Dean of the College of Liberal Arts and Sciences in 1995. Prof. Weaver is the divisional dean for the science and mathematics departments within the College, which includes supervising 10 different departments and programs. As a professor of molecular biosciences, he teaches courses in introductory molecular biology and the molecular biology of cancer. In his research laboratory, undergraduates and graduate students have participated in research on the molecular biology of a baculovirus that infects caterpillars. Prof. Weaver is the author of many scientifi c papers resulting from research funded by the National Institutes of Health, the National Science Foundation, and the American Cancer Society. He has also coauthored two genetics textbooks and has written two articles on molecular biology in the National Geographic Magazine. He has spent two years performing research in European laboratories as an American Cancer Society Research Scholar, one year in Zurich, Switzerland, and one year in Oxford, England.

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